Limbic Metabolic Abnormalities in Remote Traumatic Brain Injury and Correlation With Psychiatric Morbidity and Social Functioning
Neuropsychiatry Clin Neurosci 22:370-377, Fall
doi: 10.1176/appi.neuropsych.22.4.370
© 2010 American Neuropsychiatric Association
Arístides A. Capizzano, M.D., Ricardo E. Jorge, M.D. and Robert G. Robinson, M.D.
Received August 5, 2009; revised October 21 and November 13, 2009; accepted November 16, 2009. Dr. Capizzano is affiliated with the Department of Radiology, Division of Neuroradiology, at the University of Iowa Carver College of Medicine in Iowa City, Iowa; Drs. Jorge and Robinson are affiliated with the Department of Psychiatry at the University of Iowa Carver College of Medicine in Iowa City. Address correspondence to Aristides A. Capizzano, M.D., Department of Radiology, Division of Neuroradiology, University of Iowa Carver College of Medicine, 200 Hawkins Dr., Iowa City, IA 52242; aristides-capizzano@uiowa.edu (e-mail).
The aim of this study was to investigate limbic metabolic abnormalities in remote traumatic brain injury (TBI) and their psychiatric correlates. Twenty patients and 13 age-matched comparison subjects received complete psychiatric evaluation and brain MRI and MR spectroscopy at 3 Tesla. Patients had reduced NAA to creatine ratio in the left hippocampus relative to comparison subjects (mean=1.3 [SD=0.21] compared with mean=1.55 [SD=0.21]; F=10.73, df=1, 30, p=0.003), which correlated with the Social Functioning Examination scores (rs=–0.502, p=0.034). Furthermore, patients with mood disorders had reduced NAA to creatine ratio in the left cingulate relative to patients without mood disorders (1.47 compared with 1.68; F=3.393, df=3, 19, p=0.044). Remote TBI displays limbic metabolic abnormalities, which correlate to social outcome and psychiatric status.
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