Transcranial Magnetic Stimulation for Depression After a Traumatic Brain Injury: A Case Study.

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Transcranial Magnetic Stimulation for Depression After a Traumatic Brain Injury: A Case Study.

J ECT. 2010 Oct 5;

Authors: Fitzgerald PB, Hoy KE, Maller JJ, Herring S, Segrave R, McQueen S, Peachey A, Hollander Y, Anderson JF, Daskalakis ZJ

Depression after a traumatic brain injury (TBI) is very common, yet there is a lack of evidence-based treatment options for people who experience depression after a TBI. Traditionally, a history of TBI has been considered an exclusion criterion for transcranial magnetic stimulation trials because of the increased risk of seizure after a TBI. We present what we believe to be the first case of a patient with depression after a TBI treated with transcranial magnetic stimulation.

PMID: 20938348 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20938348&dopt=Abstract

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Dan Gardner, M.D.

www.danielgardner.yourmd.com

dgardner@ucsd.edu  858-560-5609

Apple juice improved behavioral but not cognitive symptoms in moderate-to-late stage Alzheimer's dis

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Apple juice improved behavioral but not cognitive symptoms in moderate-to-late stage Alzheimer's disease in an open-label pilot study.

Am J Alzheimers Dis Other Demen. 2010 Jun;25(4):367-71

Authors: Remington R, Chan A, Lepore A, Kotlya E, Shea TB

Preclinical studies demonstrate that apple juice exerts multiple beneficial effects including reduction of central nervous system oxidative damage, suppression of Alzheimer's disease (AD) hallmarks, improved cognitive performance, and organized synaptic signaling. Herein, we initiated an open-label clinical trial in which 21 institutionalized individuals with moderate-to-severe AD consumed 2 4-oz glasses of apple juice daily for 1 month. Participants demonstrated no change in the Dementia Rating Scale, and institutional caregivers reported no change in Alzheimer's Disease Cooperative Study (ADCS)-Activities of Daily Living (ADL) in this brief study. However, caregivers reported an approximate 27% (P < .01) improvement in behavioral and psychotic symptoms associated with dementia as quantified by the Neuropsychiatric Inventory, with the largest changes in anxiety, agitation, and delusion. This pilot study suggests that apple juice may be a useful supplement, perhaps to augment pharmacological approaches, for attenuating the decline in mood that accompanies progression of AD, which may also reduce caregiver burden.

PMID: 20338990 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20338990&dopt=Abstract

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Dan Gardner, M.D.

www.danielgardner.yourmd.com

dgardner@ucsd.edu  858-560-5609

Texture analysis of MR images of patients with mild traumatic brain injury.

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Texture analysis of MR images of patients with mild traumatic brain injury.

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Texture analysis of MR images of patients with mild traumatic brain injury.

BMC Med Imaging. 2010;10:8

Authors: Holli KK, Harrison L, Dastidar P, Wäljas M, Liimatainen S, Luukkaala T, Ohman J, Soimakallio S, Eskola H

BACKGROUND: Our objective was to study the effect of trauma on texture features in cerebral tissue in mild traumatic brain injury (MTBI). Our hypothesis was that a mild trauma may cause microstructural changes, which are not necessarily perceptible by visual inspection but could be detected with texture analysis (TA). METHODS: We imaged 42 MTBI patients by using 1.5 T MRI within three weeks of onset of trauma. TA was performed on the area of mesencephalon, cerebral white matter at the levels of mesencephalon, corona radiata and centrum semiovale and in different segments of corpus callosum (CC) which have been found to be sensitive to damage. The same procedure was carried out on a control group of ten healthy volunteers. Patients' TA data was compared with the TA results of the control group comparing the amount of statistically significantly differing TA parameters between the left and right sides of the cerebral tissue and comparing the most discriminative parameters. RESULTS: There were statistically significant differences especially in several co-occurrence and run-length matrix based parameters between left and right side in the area of mesencephalon, in cerebral white matter at the level of corona radiata and in the segments of CC in patients. Considerably less difference was observed in the healthy controls. CONCLUSIONS: TA revealed significant changes in texture parameters of cerebral tissue between hemispheres and CC segments in TBI patients. TA may serve as a novel additional tool for detecting the conventionally invisible changes in cerebral tissue in MTBI and help the clinicians to make an early diagnosis.

PMID: 20462439 [PubMed - indexed for MEDLINE]

Dan Gardner, MD

Phone/fax: 858-560-5609

www.danielgardner.yourmd.com

Texture analysis of MR images of patients with mild traumatic brain injury.

Texture analysis of MR images of patients with mild traumatic brain injury.

Related Articles

Texture analysis of MR images of patients with mild traumatic brain injury.

BMC Med Imaging. 2010;10:8

Authors: Holli KK, Harrison L, Dastidar P, Wäljas M, Liimatainen S, Luukkaala T, Ohman J, Soimakallio S, Eskola H

BACKGROUND: Our objective was to study the effect of trauma on texture features in cerebral tissue in mild traumatic brain injury (MTBI). Our hypothesis was that a mild trauma may cause microstructural changes, which are not necessarily perceptible by visual inspection but could be detected with texture analysis (TA). METHODS: We imaged 42 MTBI patients by using 1.5 T MRI within three weeks of onset of trauma. TA was performed on the area of mesencephalon, cerebral white matter at the levels of mesencephalon, corona radiata and centrum semiovale and in different segments of corpus callosum (CC) which have been found to be sensitive to damage. The same procedure was carried out on a control group of ten healthy volunteers. Patients' TA data was compared with the TA results of the control group comparing the amount of statistically significantly differing TA parameters between the left and right sides of the cerebral tissue and comparing the most discriminative parameters. RESULTS: There were statistically significant differences especially in several co-occurrence and run-length matrix based parameters between left and right side in the area of mesencephalon, in cerebral white matter at the level of corona radiata and in the segments of CC in patients. Considerably less difference was observed in the healthy controls. CONCLUSIONS: TA revealed significant changes in texture parameters of cerebral tissue between hemispheres and CC segments in TBI patients. TA may serve as a novel additional tool for detecting the conventionally invisible changes in cerebral tissue in MTBI and help the clinicians to make an early diagnosis.

PMID: 20462439 [PubMed - indexed for MEDLINE]

Dan Gardner, MD

Phone/fax: 858-560-5609

www.danielgardner.yourmd.com